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CO/Alkene Copolymers as a Promising Class of Biocompatible Materials, 1 . Examination of the In Vitro Toxicity
Author(s) -
Reuter P.,
Fuhrmann R.,
Mücke A.,
Voegele J.,
Rieger B.,
Franke R.P.
Publication year - 2003
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200390012
Subject(s) - copolymer , biocompatible material , thermoplastic elastomer , monomer , materials science , elastomer , polymer , polymer chemistry , olefin fiber , thermoplastic , alkene , polymer science , chemistry , organic chemistry , catalysis , composite material , biomedical engineering , medicine
Novel 1,4‐polyketones were synthesized by a Pd II catalyzed copolymerization reaction from cheap technical monomers. The spectrum of mechanical properties ranges from highly crystalline, hard materials to thermoplastic, soft elastomers. The hydrophilicity of the surface is adjustable from nonpolar to highly polar by a proper choice of the α ‐olefin component. This control of polymer properties is a basis for the development of new biocompatible materials. The results of standardized as well as more specific in vitro tests clearly demonstrate the nontoxicity of the investigated copolymers.Polyketone synthesis.