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Bioresorbable Hydrogels Prepared Through Stereocomplexation between Poly( L ‐lactide) and Poly( D ‐lactide) Blocks Attached to Poly(ethylene glycol)
Author(s) -
Li Suming
Publication year - 2003
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200350032
Subject(s) - lactide , ethylene glycol , polymer chemistry , copolymer , ring opening polymerization , polymerization , self healing hydrogels , differential scanning calorimetry , peg ratio , zinc , chemistry , materials science , polymer , organic chemistry , physics , finance , economics , thermodynamics
Block copolymers were synthesized by ring‐opening polymerization of L ‐lactide or D ‐lactide in the presence of mono‐ or dihydroxyl poly(ethylene glycol), using zinc metal as catalyst. The resulting copolymers were characterized by various techniques, namely 1 H NMR spectroscopy, differential scanning calorimetry (DSC), X‐ray diffractometry, and Raman spectrometry. The composition of the copolymers was designed such that they were water soluble. Bioresorbable hydrogels were prepared from aqueous solutions containing both poly( L ‐lactide)/poly(ethylene glycol) and poly( D ‐lactide)/poly(ethylene glycol) block copolymers. Rheological studies confirmed the formation of hydrogels resulting from stereocomplexation between poly( L ‐lactide) and poly( D ‐lactide) blocks.Ring‐opening polymerization of L ( D )‐lactide in the presence of dihydroxyl PEG using zinc powder as catalyst.