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N ‐(2‐Hydroxypropyl)methacrylamide (HPMA) Copolymer‐Linked Nitroxides: Potential Magnetic Resonance Contrast Agents
Author(s) -
Huang Yuan,
Nan Anjan,
Rosen Gerald M.,
Winalski Carl S.,
Schneider Erika,
Tsai Pei,
Ghandehari Hamidreza
Publication year - 2003
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200350031
Subject(s) - copolymer , methacrylamide , nitroxide mediated radical polymerization , chemistry , polymer chemistry , gadolinium , macromolecule , radical polymerization , polymer , acrylamide , organic chemistry , biochemistry
N ‐(2‐Hydroxypropyl)methacrylamide (HPMA) copolymer‐linked nitroxides were synthesized as macromolecular contrast agents for MR imaging. Molar relaxivities of HPMA copolymer‐linked nitroxides increased linearly in proportion to the number of nitroxides attached per gram of copolymer. HPMA copolymer‐linked nitroxides with 15, 20 and 30 mol‐% nitroxide exhibited higher relaxivities than gadolinium diethylenetriaminepentaacetic acid (Gd‐DTPA). These results demonstrate the potential of HPMA copolymer‐linked nitroxides as MR contrast agents for solid tumors.Structure of HPMA copolymer‐linked nitroxides.