Premium
Polyelectrolyte Complex Films Derived from Polyethyleneoxide‐Maleic Acid Copolymer and Chitosan: Preparation and Characterization
Author(s) -
ShinYa Yoshitsune,
Tsurushima Hideo,
Tsurumi Taro,
Kajiuchi Toshio,
Leong Kam W.
Publication year - 2004
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200300110
Subject(s) - polyelectrolyte , copolymer , maleic acid , swelling , chitosan , solvent , chemical engineering , polymer chemistry , morphology (biology) , drug delivery , materials science , chemistry , nuclear chemistry , organic chemistry , polymer , biology , engineering , genetics
Summary: Polyelectrolyte complex films were prepared with polyethyleneoxide‐maleic acid copolymer and chitosan using a casting/solvent evaporation method. The films were examined in terms of their IR spectra, surface and cross‐section morphologies, cytotoxicity, and swelling behavior at different pH levels. To assess the potential of these films as a biomedical device, the profiles of the release of model drug from the CS/PEOMA films were examined at pH 4.8. The surface morphology of the films was quite smooth and uniform, and the cross‐sectional morphology was dense and homogeneous. The swelling behaviors of CS/PEOMA films were found to depend on the pH of the solution as well as on the CS/PEOMA composition. Drug release from different CS/PEOMA films at pH 4.8 was found to be dependent on film composition. The results showed the potential applicability of CS/PEOMA film as a drug delivery vehicle.