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Erosion Induced Controllable Release of Gliclazide Encapsulated Inside Degradable Polymeric Particles
Author(s) -
Zhao Yue,
Chen Wenna,
Cai Qing,
Wang Shenguo,
Bo Jun,
Wu Chi
Publication year - 2004
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200300061
Subject(s) - gliclazide , chemical engineering , copolymer , particle size , particle (ecology) , degradation (telecommunications) , ethylene oxide , materials science , kinetics , chemistry , polymer chemistry , polymer , composite material , engineering , endocrinology , medicine , telecommunications , oceanography , physics , quantum mechanics , geology , computer science , insulin
Summary: The microphase inversion of water‐insoluble poly( L ‐lactide), “poly[( L ‐lactide)‐ co ‐glycolide] and polylactide‐ block ‐poly(ethylene oxide)‐ block ‐polylactide from THF to water can result in narrowly distributed stable particles. Gliclazide, a commercial drug, can be encapsulated inside during the process. The formation and degradation of such particles was studied by laser light scattering. In comparison with the corrosion of a bulk material, the degradation of each particle is so fast that we only detect the decrease of the particle number, not the corrosion of individual particles. Therefore, the degradation is a “one‐by‐one” random process, just like the chemical reaction of molecules in solution. The disappearing rate of the particle number is nearly independent of time, ideal for the controlled release of drugs encapsulated inside. The amount of encapsulated gliclazide depends on the copolymer's hydrophobicity (composition), while the releasing rate mainly is, directly related to the disappearing rate of the particles. The correlation between the fluorescence intensity and the degradation was used to study the kinetics of gliclazide releasing. The releasing pattern is controllable with a proper choice of the drug loading, copolymer composition, pH and temperature.