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Sustained Release of BSA from a Novel Drug Delivery Matrix – Bullfrog Skin Collagen Film
Author(s) -
Li He,
Wang Diqiang,
Li Songjun,
Liu Bailing,
Gao Lizhen
Publication year - 2004
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200300039
Subject(s) - bullfrog , bovine serum albumin , chemistry , drug delivery , matrix (chemical analysis) , biophysics , swelling , biochemistry , materials science , chromatography , biology , endocrinology , organic chemistry , composite material
Summary: A novel drug delivery system, bullfrog skin collagen film, was employed to release bovine serum albumin (BSA). The biophysical properties of bullfrog skin collagen film used were evaluated by thermal denaturation temperature and percentage water loss. The film obtained exhibited good stability and can be taken as a good candidate for drug delivery matrix. Compared with conventional collagen from molecular weight and amino acid composition, bullfrog skin collagen showed significant differences. For safety considerations, bullfrog skin collagen has great advantages. The release kinetics of BSA from bullfrog skin collagen film was measured in vitro. The results indicated bullfrog skin collagen film could be used for sustained release of BSA. Thus, bullfrog skin collagen film can be taken as a novel drug delivery system.Morphology of frog collagen film with drug loaded after release.