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Studies on the Synthesis and Properties of Temperature Responsive and Biodegradable Hydrogels
Author(s) -
Sun LiFang,
Zhuo RenXi,
Liu ZhiLan
Publication year - 2003
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.200300012
Subject(s) - self healing hydrogels , copolymer , polymer chemistry , chemistry , degradation (telecommunications) , biodegradation , chemical engineering , materials science , polymer , organic chemistry , telecommunications , computer science , engineering
Novel linear poly(NIPA‐ co ‐CL) copolymers have been synthesized by radical copolymerization of N ‐isopropylacrylamide (NIPA) and 2‐methylene‐1,3‐dioxepane (MDO). The structure of copolymers was confirmed by 1 H NMR and IR spectroscopy. Cross‐linked poly(NIPA‐ co ‐CL) hydrogels have also been prepared in toluene using N , N ′‐methylenebisacrylamide as cross‐linking agent. The hydrogels thus obtained exhibit good temperature response and are biodegradable in the presence of proteinase K.Temperature influence on the enzymatic degradation by proteinase K of poly(NIPA‐ co ‐CL) hydrogel (G‐60).