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Late recurrence and rapid evolution of severe hepatopulmonary syndrome after liver transplantation
Author(s) -
Krowka Michael J.,
Wiseman Gregory A.,
Steers Jeffery L.,
Wiesner Russell H.
Publication year - 1999
Publication title -
liver transplantation and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1074-3022
DOI - 10.1002/lt.500050502
Subject(s) - hepatopulmonary syndrome , medicine , nonalcoholic steatohepatitis , liver transplantation , sepsis , hypoxemia , liver biopsy , surgery , gastroenterology , orthotopic liver transplantation , transplantation , biopsy , nonalcoholic fatty liver disease , fatty liver , disease
Recurrence of hepatopulmonary syndrome (HPS) after orthotopic liver transplantation (OLT) in an adult has never been reported. We describe a 23‐year‐old woman who initially underwent OLT because of debilitating and severe HPS associated with nonalcoholic steatohepatitis (NASH). Although the clinical resolution of HPS was well documented day 117 post‐OLT, the reappearance of NASH was documented by liver biopsy. Severe hypoxemia because of recurrent HPS rapidly evolved beginning approximately day 700 post‐OLT. Retransplantation was attempted, but the patient died post‐OLT of sepsis and/or multiorgan failure.