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Fulminant epstein‐barr viral hepatitis: Orthotopic liver transplantation and review of the literature
Author(s) -
Feranchak Andrew P.,
Tyson R. Weslie,
Narkewicz Michael R.,
Karrer Frederick M.,
Sokol Ronald J.
Publication year - 1998
Publication title -
liver transplantation and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1074-3022
DOI - 10.1002/lt.500040612
Subject(s) - fulminant hepatic failure , immunosuppression , medicine , fulminant , fulminant hepatitis , liver transplantation , transplantation , epstein–barr virus , viral hepatitis , immunology , primary immunodeficiency , antibody , virus , disease , lymphoproliferative disorders , lymphoma
Acute hepatic failure caused by primary Epstein‐Barr virus (EBV) infection has been reported in the literature in 16 cases, with an overall mortality of 87%. We report a case of fulminant hepatic failure in an immunocompetent young girl caused by primary EBV infection that was treated by orthotopic liver transplantation. After transplantation she has been treated with low‐dose immunosuppression, a pooled gammaglobulin preparation containing anti‐EBV antibodies, and anti‐viral therapy. The patient is presently doing well 2 years after transplantation without evidence of clinical EBV infection, primary immunodeficiency, or lymphoproliferative disease.