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Severe pulmonary hypertension and amelioration of hepatopulmonary syndrome after liver transplantation
Author(s) -
Kaspar Melanie D.,
Ramsay, Michael A.E.,
Shuey Charles B.,
Levy Marlon F.,
Klintmalm Goran G.B.
Publication year - 1998
Publication title -
liver transplantation and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1074-3022
DOI - 10.1002/lt.500040201
Subject(s) - hepatopulmonary syndrome , medicine , liver transplantation , pulmonary hypertension , transplantation , cardiology
A patient with end‐stage liver disease as a result of α 1 ‐antitripsin deficiency presented for orthotopic liver transplantation. The liver cirrhosis was complicated by portal hypertension and hepatopulmonary syndrome resulting in varicosities and severe hypoxia (room air oxygen saturation 69%). After transplantation, the hepatopulmonary syndrome improved but, over the next 14 months, the patient developed severe pulmonary hypertension. Six years posttransplantation, his room air oxygen saturation was 95% with pulmonary artery pressures of 109 mm Hg systolic and 26 mm Hg diastolic (mean 55 mm Hg) and a pulmonary vascular resistance 688 dynes·sec·cm. 5