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Persistent cortical blindness after cyclosporine leukoencephalopathy
Author(s) -
Casanova B,
Prieto M,
Deya E,
Gisbert C,
Mir J,
Berenguer J,
Vilchez J J
Publication year - 1997
Publication title -
liver transplantation and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1074-3022
DOI - 10.1002/lt.500030614
Subject(s) - cortical blindness , discontinuation , medicine , leukoencephalopathy , magnetic resonance imaging , complication , blindness , liver transplantation , transplantation , pediatrics , surgery , gastroenterology , radiology , optometry
Cyclosporine A (CyA)‐related cortical blindness is an uncommon complication of CyA therapy in patients undergoing liver transplantation. Characteristically, neurological symptoms associated with CyA treatment usually regress after cyclosporine withdrawal. We present a case of a liver transplant recipient in whom discontinuation of CyA therapy has resulted in only partial clinical improvement, and cortical blindness remains after 1 year of follow‐up. The evolution of cerebral magnetic resonance imaging (MRI) findings over time in this form of CyA leukoencephalopathy is also described.