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Regeneration of a transplanted liver after right hepatic lobectomy
Author(s) -
Chari Ravi S.,
Baker Mark E.,
Sue Sean R.,
Meyers William C.
Publication year - 1996
Publication title -
liver transplantation and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1074-3022
DOI - 10.1002/lt.500020309
Subject(s) - regeneration (biology) , liver regeneration , hepatectomy , medicine , biology , surgery , microbiology and biotechnology , resection
Liver regeneration has been described after heterotopic liver transplantation, small‐for‐size orthotopic liver transplantation and reduced‐size liver transplantation. In this report, we document the regenerative response of a whole liver transplant to major resection for the first time. A right hepatic lobectomy for liver ischemia was performed in a 30‐year‐old female after transplantation for autoimmune disease of the liver. Volumetric analysis of computed tomography (CT) scans revealed a preoperative liver volume of 1,961 mL, whereas analysis of the 6‐week posthepatectomy CT scan showed a volume of 1,820 mL. Factors influencing regeneration in the setting of a liver transplant include rejection, ischemia/thrombosis, infection, or cyclosporine hepatotrophic/hepatotoxic effects. These factors, balanced with the intrinsic ability of hepatocytes to achieve a standard liver volume, determine the extent of regeneration. Copyright © 1996 by the American Association for the Study of Liver Diseases.