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Hepatitis C virus genotypes, hepatitis, and hepatitis C virus recurrence after liver transplantation
Author(s) -
Belli Luca S.,
Silini Enrico,
Alberti Alberto,
Bellati Giorgio,
Vai Claudio,
Minola Ernesto,
Rondinara Gianfranco,
De Carlis Luciano,
Asti Margherita,
Forti Domenico,
Ideo Gaetano
Publication year - 1996
Publication title -
liver transplantation and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1074-3022
DOI - 10.1002/lt.500020305
Subject(s) - liver transplantation , medicine , hepatitis c virus , hepatitis c , cirrhosis , genotype , hepatitis , liver disease , transplantation , liver biopsy , genotyping , gastroenterology , virology , virus , biopsy , biology , gene , biochemistry
Several genotypes of hepatitis C virus (HCV) have been recently identified by phylogenetic analysis, but their clinical relevance in the liver transplant setting is unknown. We evaluated the incidence and course of recurrent hepatitis C after transplantation in 50 patients who underwent transplantation for HCV‐related liver disease. Liver biopsy specimens were obtained when clinically indicated and at yearly intervals; hepatitis was histologically graded and staged according to standard criteria. HCV‐RNA was detected by nested reverse‐transcription polymerase chain reaction (RT‐PCR). HCV genotyping was performed by primer specific PCR. Follow‐up was 6 to 62 months. HCV genotype distribution after transplantation of our 50 patients was as follows: 31 type 1b, 13 type 2a, 3 type 1a, 1 type 3a, 1 type 1b/2a, and 1 undetermined. Actuarial rates of recurrent hepatitis and of severe fibrosis or cirrhosis 5 years after transplantation were 56% and 20%, respectively, in patients infected by type 1b and 33% ( P = .18) and 8% ( P = .16) in those infected by 2a. In conclusion, this study provides evidence that in patients infected by HCV type 1b there is a trend for a more aggressive recurrent liver disease. Copyright © 1996 by the American Association for the Study of Liver Diseases.