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Progressive multifocal leukoencephalopathy after orthotopic liver transplantation
Author(s) -
Bronster David J.,
Lidov Mika W.,
Wolfe David,
Schwartz Myron E.,
Miller Charles M.
Publication year - 1995
Publication title -
liver transplantation and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1074-3022
DOI - 10.1002/lt.500010606
Subject(s) - progressive multifocal leukoencephalopathy , medicine , leukoencephalopathy , brain biopsy , hemiparesis , transplantation , liver transplantation , white matter , demyelinating disease , jc virus , pathology , magnetic resonance imaging , biopsy , disease , radiology , surgery , multiple sclerosis , immunology , lesion
Six weeks after liver transplantation, a 51‐year‐old man developed a slowly progressive hemiparesis with deteriorating mental status and seizures. Successive computed tomography (CT) scans of the brain revealed unilateral nonenhancing white matter lucencies that gradually coalesced and progressed to both hemispheres. Brain biopsy results were consistent with progressive multifocal leukoencephalopathy (PML). We believe this is the first antemortem description of PML after liver transplantation. Herein, we describe the case and review the literature on PML after solid organ transplantation. Early recognition of this central nervous system disease may be important with new advances in therapy of this viral infection of the immunocompromised patient.