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Seroconversion After Coronavirus Disease 2019 Vaccination in Patients Awaiting Liver Transplantation: Fact or Fancy?
Author(s) -
Calleri Alberto,
Saracco Margherita,
Pittaluga Fabrizia,
Cavallo Rossana,
Romagnoli Renato,
Martini Silvia
Publication year - 2022
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.26312
Subject(s) - medicine , vaccination , seroconversion , interquartile range , liver transplantation , transplantation , antibody , gastroenterology , immunology
Chronic liver disease increased the risk of severe coronavirus disease 2019 (COVID‐19). Trials to assess efficacy/safety of COVID‐19 vaccines in liver disease are underway. We evaluated the humoral immune response and safety of anti–COVID‐19 vaccination among patients waiting liver transplantation (LT). We enrolled all pre‐LT adults who completed anti‐COVID‐19 vaccination between January 2021‐August 2021 as study group. Patients with histories of COVID‐19 received 1 vaccine dose, and all others received 2 doses. Patients were tested for COVID‐19 immunoglobulin G (IgG) within 1 and 2 months after vaccination. Safety was evaluated with telephone interviews/outpatient visits. A control group of 30 healthcare workers who underwent vaccination in January 2021 and tested for IgG after 4 months was included. In the 89 pre‐LT patients, at T1 (23 days after vaccination), seroconversion rate was 94.4%, and median IgG value was 1980 binding antibody units/mL (interquartile range 646‐2080), and at T2 (68 days after vaccination) was 92.0%, with IgG value of 1450 (577‐2080); (T1 versus T2, P = 0.38). In the 10/89 patients who received 1 vaccine dose, the median IgG value was 274 (68‐548) before vaccine (T0), 2080 (1165‐2080) at T1, and 2030 (964‐2080) at T2 (T0 versus T1, P = 0.03; T1 versus T2, P = 0.99). All controls tested positive at 4 months after vaccination, with a median value of 847 (509‐1165; P < 0.001 versus T1 and P = 0.04 versus T2 in the study group). No serious adverse event was reported in both groups. Our data from 89 pre‐LT patients suggest a high rate of immunization (94.4%) after a median time of 23 days from safe COVID‐19 vaccine. None of the patients developed COVID‐19.