Premium
Longterm results of liver transplantation from donation after circulatory death
Author(s) -
Blok Joris J.,
Detry Olivier,
Putter Hein,
Rogiers Xavier,
Porte Robert J.,
van Hoek Bart,
Pirenne Jacques,
Metselaar Herold J.,
Lerut Jan P.,
Ysebaert Dirk K.,
Lucidi Valerio,
Troisi Roberto I.,
Samuel Undine,
den Dulk A. Claire,
Ringers Jan,
Braat Andries E.
Publication year - 2016
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.24449
Subject(s) - medicine , hazard ratio , liver transplantation , proportional hazards model , surgery , survival analysis , donation , transplantation , survival rate , confidence interval , economics , economic growth
Donation after circulatory death (DCD) liver transplantation (LT) may imply a risk for decreased graft survival, caused by posttransplantation complications such as primary nonfunction or ischemic‐type biliary lesions. However, similar survival rates for DCD and donation after brain death (DBD) LT have been reported. The objective of this study is to determine the longterm outcome of DCD LT in the Eurotransplant region corrected for the Eurotransplant donor risk index (ET‐DRI). Transplants performed in Belgium and the Netherlands (January 1, 2003 to December 31, 2007) in adult recipients were included. Graft failure was defined as either the date of recipient death or retransplantation whichever occurred first (death‐uncensored graft survival). Mean follow‐up was 7.2 years. In total, 126 DCD and 1264 DBD LTs were performed. Kaplan‐Meier survival analyses showed different graft survival for DBD and DCD at 1 year (77.7% versus 74.8%, respectively; P = 0.71), 5 years (65.6% versus 54.4%, respectively; P = 0.02), and 10 years (47.3% versus 44.2%, respectively; P = 0.55; log‐rank P = 0.038). Although there was an overall significant difference, the survival curves almost reach each other after 10 years, which is most likely caused by other risk factors being less in DCD livers. Patient survival was not significantly different ( P = 0.59). Multivariate Cox regression analysis showed a hazard ratio of 1.7 ( P < 0.001) for DCD (corrected for ET‐DRI and recipient factors). First warm ischemia time (WIT), which is the time from the end of circulation until aortic cold perfusion, over 25 minutes was associated with a lower graft survival in univariate analysis of all DCD transplants ( P = 0.002). In conclusion, DCD LT has an increased risk for diminished graft survival compared to DBD. There was no significant difference in patient survival. DCD allografts with a first WIT > 25 minutes have an increased risk for a decrease in graft survival. Liver Transplantation 22 1107–1114 2016 AASLD