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The changing face of liver transplantation for acute liver failure: Assessment of current status and implications for future practice
Author(s) -
Donnelly Mhairi C.,
Hayes Peter C.,
Simpson Kenneth J.
Publication year - 2016
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.24403
Subject(s) - medicine , liver transplantation , etiology , intensive care medicine , transplantation , liver failure , liver disease , disease
The etiology and outcomes of acute liver failure (ALF) have changed since the definition of this disease entity in the 1970s. In particular, the role of emergency liver transplantation has evolved over time, with the development of prognostic scoring systems to facilitate listing of appropriate patients, and a better understanding of transplant benefit in patients with ALF. This review examines the changing etiology of ALF, transplant benefit, outcomes following transplantation, and future alternatives to emergency liver transplantation in this devastating condition. Liver Transplantation 22 527‐535 2016 AASLD