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Longterm corticosteroid use after liver transplantation for autoimmune hepatitis is safe and associated with a lower incidence of recurrent disease
Author(s) -
Krishnamoorthy Thinesh L.,
MiezynskaKurtycz Joanna,
Hodson James,
Gunson Bridget K.,
Neuberger James,
Milkiewicz Piotr,
Oo Ye H.
Publication year - 2016
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.24323
Subject(s) - medicine , autoimmune hepatitis , interquartile range , osteoporosis , liver transplantation , sepsis , gastroenterology , osteopenia , surgery , transplantation , cohort , liver disease , incidence (geometry) , hepatitis , bone mineral , physics , optics
Patients transplanted for autoimmune hepatitis (AIH) are at risk of recurrent disease. Our current practice is to maintain long‐term low‐dose corticosteroids with additional immunosuppressive agents. This study describes the implications on patients' outcomes, sepsis, and osteoporosis. We collected data on patients transplanted between January 1999 and October 2014 in a single center who survived for more than 6 months. AIH recurrence was diagnosed by a combination of histology, raised immunoglobulin G levels, and exclusion of other etiologies. Sepsis was defined as any infection that resulted in significant morbidity or mortality. Osteoporosis was defined as a bone densitometry T score of less than −2.0 or evidence of osteoporosis‐related fractures. Outcomes were assessed using Kaplan‐Meier survival analysis methods. Seventy‐three AIH patients underwent liver transplantation with a median follow‐up of 94 months (interquartile range, 55‐144). The cohort was mainly Caucasian (78%), female (79%), with type 1 AIH (90%), and a mean age of 43 ± 15 years. Overall survival was 92%, 90%, 86%, and 73%, and regraft‐free survival was 86%, 81%, 78%, and 64% at 1, 3, 5, and 10 years, respectively. Five patients developed AIH recurrence, giving recurrence rates of 0%, 4%, 6%, and 11% at 1, 3, 5, and 10 years, respectively. Pneumonia was the most common infection, but gastroenteritis and cholangitis were the most recurrent. Freedom from sepsis was 91%, 82%, 80%, and 63%, and freedom from osteoporosis was 100%, 94%, 82%, and 58% at 1, 3, 5, and 10 years, respectively. Longterm low‐dose corticosteroid in combination with other immunosuppressive agents seems to reduce AIH recurrence without jeopardizing patient and graft survival. Sepsis and osteoporosis did not occur more often compared to the published literature on liver transplant recipients. Liver Transpl 22:34‐41, 2016 . © 2015 AASLD.