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Prerecovery liver biopsy in the brain‐dead donor: A case‐control study of logistics, safety, precision, and utility
Author(s) -
Oliver Joseph Benton,
Peters Stephen,
Bongu Advaith,
Beidas AbdelKareem,
Dikdan George,
Brown Lloyd,
Koneru Baburao
Publication year - 2014
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.23786
Subject(s) - medicine , steatosis , liver transplantation , biopsy , liver biopsy , fibrosis , gastroenterology , surgery , transplantation
Prerecovery liver biopsy (PLB) can potentially to decrease futile recovery and increase utilization of marginal brain‐dead donor (BDD) livers. A case‐control study was conducted to examine the logistics, safety, histological precision, and liver utilization associated with PLB in BDDs. Twenty‐three cases between January 2008 and January 2013 were compared to 2 groups: 48 sequential and 69 clinically matched controls. Compared to the sequential controls, the cases were older (53 versus 46 years), heavier (30.2 versus 25.8 kg/m 2 ), had higher prevalences of hypertension (78.3% versus 44.7%) and alcohol use (56.5% versus 23.4%), and a lower United Network for Organ Sharing expected organ yield (0.73 versus 0.81 livers/donor; P < 0.05 for all). Baseline characteristics were similar between cases and clinical controls. Donor management time was longer for the cases (22.4 hours) versus sequential controls (16.5 hours, P = 0.01) and clinical controls (15.9 hours, P = 0.01). Complications for cases (8.7%) were not different from either group of controls (18.8% for sequential controls, P = 0.46; 17.4% for clinical controls, P = 0.50). The agreement between the donor hospital and study pathologists was substantial regarding evaluation of steatosis (κ = 0.623) and fibrosis (κ = 0.627) and moderate regarding inflammation (κ = 0.495). The proportions of livers that were transplanted were similar for the cases and the clinical controls (60.9% versus 59.4%). In contrast, the proportion of donors for whom liver recovery was not attempted was higher (30.4% versus 8.7%), and the proportion of attempted liver recoveries that did not result in transplantation was lower (8.7% versus 31.9%). These differences were significant at P = 0.009. Overall, PLB is logistically feasible with only a minimal delay and is safe, its interpretation at donor hospitals is reproducible, and it appears to decrease futile liver recovery. Liver Transpl 20:237‐244, 2014 . © 2013 AASLD.