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Bridging the gap: Advances in artificial liver support
Author(s) -
Nyberg Scott L.
Publication year - 2012
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.23506
Subject(s) - bioartificial liver device , detoxification (alternative medicine) , medicine , liver transplantation , economic shortage , proinflammatory cytokine , bridging (networking) , liver failure , liver function , intensive care medicine , transplantation , surgery , hepatocyte , pathology , computer science , inflammation , biology , biochemistry , computer network , linguistics , philosophy , alternative medicine , government (linguistics) , in vitro
Key Points 1. The goals of liver support therapy include the following: • To provide detoxification and synthetic function during liver failure. • To remove or reduce the production of proinflammatory cytokines to correct the systemic inflammatory response of liver failure. • To stimulate the regeneration of the injured liver and increase the likelihood of spontaneous recovery. 2. There is a large unmet need for a liver support device because of the shortage of organs for liver transplantation and the risks of major surgery. 3. Liver support devices can be divided into 2 groups: purely mechanical artificial devices and cell‐based bioartificial devices. Both provide detoxification, but bioartificial liver devices provide the option of synthetic function and biotransformation activities that are not possible with a purely mechanical device. 4. An abundant high‐quality supply of human hepatocytes is not currently available for liver cell therapy. However, such a supply is essential for successful bioartificial liver therapy. Novel options are under development for the unlimited production of high‐quality human hepatocytes. Liver Transpl, 2012. © 2012 AASLD.