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Assist devices: Machine preservation of extended criteria donors
Author(s) -
Guarrera James V.
Publication year - 2012
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.23505
Subject(s) - medicine , machine perfusion , liver transplantation , clinical trial , reperfusion injury , liver injury , perfusion , transplantation , surgery , liver function , ischemia , intensive care medicine
Key Points 1. Hypothermic machine perfusion (HMP) is in its infancy in clinical liver transplantation. Potential benefits include diminished preservation injury (PI) and improved graft function. 2. We have employed HMP in 21 extended criteria donor (ECD livers) at our center with excellent clinical outcomes. 3. Our experience with liver HMP is the only reported clinical experience worldwide representing a total of 41 successful liver transplant cases showing improved outcomes and diminished markers of ischemia/reperfusion injury. 4. Further multicenter and large scale trials are now warranted to further explore the benefits and applicability of liver HMP into the clinical mainstream. Liver Transpl, 2012. © 2012 AASLD.