Premium
Risk of advanced fibrosis with grafts from hepatitis C antibody–positive donors: A multicenter cohort study
Author(s) -
Lai Jennifer C.,
O'Leary Jacqueline G.,
Trotter James F.,
Verna Elizabeth C.,
Brown Robert S.,
Stravitz R. Todd,
Duman Jeffrey D.,
Forman Lisa M.,
Terrault Norah A.
Publication year - 2012
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.23396
Subject(s) - medicine , hepatitis c virus , hepatitis c , gastroenterology , fibrosis , liver transplantation , cohort , transplantation , immunology , virus
Over the last decade, the use of liver grafts from hepatitis C virus antibody–positive donors [HCV(+)Ds] has tripled in the United States. Although previous studies have demonstrated no association between an HCV(+)D status and graft loss, the effects of an HCV(+)D on histological outcomes are not well known. Hepatitis C virus (HCV)–infected recipients at 5 US centers (2002‐2007) who survived more than 30 days with 1 or more posttransplant biopsy samples were included. Cox regression was used to examine the association between an HCV(+)D status and advanced fibrosis (stage 3/4 or higher). Ninety‐nine of the 1206 patients (8%) received an HCV(+)D graft. Recipients of HCV(+)D grafts were older than recipients of hepatitis C virus antibody–negative donor [HCV(−)D] grafts ( P = 0.03), but they were otherwise similar. HCV(+)D grafts were significantly lower in quality according to the donor risk index ( P < 0.001). Advanced fibrosis occurred in 32% of HCV(+)D graft recipients and in 28% of HCV(−)D graft recipients ( P = 0.39). The unadjusted 1‐ and 3‐year rates of advanced fibrosis were significantly higher for HCV(+)D graft recipients (14% and 48%) versus HCV(−)D graft recipients (7% and 33%, P = 0.01). Transplantation with HCV(+)D grafts was associated with a 58% increased risk of advanced fibrosis [95% confidence interval (CI) = 1.05‐2.36, P = 0.03]. However, in an analysis stratified by the mean donor age of 45 years, an HCV(+)D status was associated with advanced fibrosis only with donors >45 years old [hazard ratio (HR) = 1.76, 95% CI = 1.06‐2.93, P = 0.03] and not with donors ≤45 years old (HR = 0.94, 95% CI = 0.47‐1.87, P = 0.85). In conclusion, a careful consideration of the risks and benefits is needed with HCV(+)D grafts. Recipients of HCV(+)D grafts (especially from older donors) should undergo close monitoring for more rapidly progressive fibrosis. Studies are needed to determine whether early HCV therapy modifies this risk. Liver Transpl, 2012. © 2012 AASLD.