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Hot‐topic debate on hepatitis C virus: The type of immunosuppression matters
Author(s) -
Trotter James F.
Publication year - 2011
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.22414
Subject(s) - medicine , immunosuppression , liver transplantation , hepatitis c virus , calcineurin , hepatitis c , liver disease , tacrolimus , immunology , gastroenterology , transplantation , virus
Key Points 1. The treatment of rejection is an important factor associated with the severe recurrence of hepatitis C virus (HCV) after liver transplantation. 2. The effects of calcineurin inhibitors, corticosteroids, and mycophenolate mofetil on HCV recurrence are equivocal. 3. Cyclosporine is associated with a higher sustained virological response in patients treated for HCV. 4. Because insulin resistance and diabetes are associated with fibrosis in HCV‐infected liver transplant recipients, the use of immunosuppressive agents without this side effect may slow the posttransplant disease progression. Liver Transpl, 2011. © 2011 AASLD.