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Hepatosplenic γδ T‐cell lymphoma after liver transplantation: Report of the first 2 cases and review of the literature
Author(s) -
Roelandt Philip R.,
Maertens Johan,
Vandenberghe Peter,
Verslype Chris,
Roskams Tania,
Aerts Raymond,
Nevens Frederik,
Dierickx Daan
Publication year - 2009
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.21748
Subject(s) - medicine , pathological , liver transplantation , lymphoproliferative disorders , lymphoma , pathology , spleen , transplantation , infiltration (hvac) , immunology , physics , thermodynamics
Abstract Hepatosplenic γδ T‐cell lymphoma is a rare lymphoproliferative disorder originating from natural killer–like Vδ1‐lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation. Both patients had thrombocytopenia with (hepato)splenomegaly but without peripheral lymphadenopathies and sinusoidal infiltration of the liver and spleen by monomorphic γδ‐lymphocytes on pathological examination. The clinical and pathological findings, immunophenotypical profile, prognosis, and treatment are highlighted. In order to make an early diagnosis, physicians who take care of liver transplant recipients should be aware of the characteristic features of this posttransplant lymphoproliferative disorder. Therefore, a diagnostic algorithm is proposed. Liver Transpl 15:686–692, 2009. © 2009 AASLD.