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How to diagnose and treat hepatitis B virus antiviral drug resistance in the liver transplant setting
Author(s) -
Lok Anna S. F.
Publication year - 2008
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.21616
Subject(s) - medicine , hepatitis b virus , drug resistance , hepatitis c virus , hepatitis b , virology , antiviral drug , liver transplantation , virus , drug , antiviral therapy , immunology , transplantation , pharmacology , chronic hepatitis , biology , microbiology and biotechnology
Abstract Key Points1 Hepatitis B virus variants with antiviral drug–resistant mutations and/or hepatitis B immune globulin–resistant mutations are the main cause of hepatitis B virus reinfections post–liver transplant. 2 Early diagnosis of antiviral drug resistance and prompt initiation of rescue therapy are important in preventing hepatitis flares and hepatic decompensation. 3 Virologic breakthrough is the first indication of antiviral drug resistance. 4 Genotypic resistance testing should be performed when possible to avoid unnecessary modification of treatment in patients who do not have confirmed antiviral drug resistance and to permit appropriate selection of rescue therapy in those who have confirmed antiviral drug resistance. 5 Choice of rescue therapy requires knowledge of the past history of hepatitis B virus treatments and virologic response to those treatments, patterns of mutations detected at the time of virologic breakthrough, and in vitro cross‐resistance data. 6 Occurrence of antiviral drug resistance can be reduced by the use of the most potent nucleos(t)ide analogue(s) with the highest genetic barrier to resistance, emphasis of medication compliance, and close monitoring of virologic response.Liver Transpl 14:S8–S14, 2008. © 2008 AASLD.