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Transplantation‐mediated alloimmune thrombocytopenia: Guidelines for utilization of thrombocytopenic donors
Author(s) -
Diaz Geraldine C.,
Prowda Joan,
Lo Irene J.,
Arepally Gowthami M.,
Evans Neal,
Wheeless Yvonne,
Samstein Benjamin,
Guarrera James V.,
Renz John F.
Publication year - 2008
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.21539
Subject(s) - medicine , liver transplantation , transplantation , intensive care medicine , medline , immunology , political science , law
Transplantation‐mediated alloimmune thrombocytopenia (TMAT) is donor‐derived thrombocytopenia following solid‐organ transplantation. To date, no clear consensus on the appropriateness of organ utilization from cadaver donors with a history of idiopathic thrombocytopenia purpura (ITP) has emerged. Herein is reported a devastating case of TMAT following liver transplantation utilizing an allograft from a donor with ITP that resulted in allograft failure. The literature is reviewed in this context to propose preliminary guidelines regarding utilization of allografts from cadaver donors with a history of ITP. Liver Transpl 2008;14:1803–1809. © 2008 AASLD.