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Effect of antibiotic prophylaxis on the risk of surgical site infection in orthotopic liver transplant
Author(s) -
Asensio Angel,
Ramos Antonio,
CuervasMons Valentin,
Cordero Elisa,
SánchezTurrión Victor,
Blanes Marino,
Cervera Carlos,
Gavalda Joan,
Aguado Jose M.,
TorreCisneros Julian
Publication year - 2008
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.21435
Subject(s) - medicine , odds ratio , liver transplantation , surgery , antibiotic prophylaxis , confidence interval , incidence (geometry) , transplantation , antibiotics , microbiology and biotechnology , physics , optics , biology
Surgical site infections are common bacterial infections in orthotopic liver transplantation. The purpose of this study was to determine the incidence, timing, location, and risk factors, specifically antibiotic prophylaxis, for surgical site infections. A prospective study was performed that included a population of 1222 consecutive patients (73.0% males) who underwent liver transplantation in Spanish hospitals belonging to the Red de Estudio de la Infección en el Trasplante research network. One hundred seven patients developed surgical site infections. The predominant infection sites were incisional wound (53 episodes) and peritonitis (40 episodes). The timing of the organ/space surgical site infections was slightly delayed in comparison with incisional surgical site infections. Enterococcus spp., Escherichia coli , Staphylococcus aureus , and Acinetobacter baumannii were the predominant pathogens. Choledochojejunal or hepaticojejunal reconstruction (odds ratio, 4.2; 95% confidence interval, 1.6–10.7), previous liver or kidney transplant (odds ratio, 2.6; 95% confidence interval, 1.1–6.3), and more than 4 red blood cell units transfused (odds ratio, 2.0; 95% confidence interval, 1.1–3.4) were independently associated with the development of surgical site infections. Biliary reconstruction by choledochojejunostomy or hepaticojejunostomy increases the risk of surgical site infections. Liver Transpl 14:799–805, 2008. © 2008 AASLD.