Premium
Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus
Author(s) -
Bhagat Vishal,
Foont Julie A.,
Schiff Eugene R.,
Regev Arie
Publication year - 2008
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.21351
Subject(s) - medicine , coinfection , hepatitis c virus , liver transplantation , hepatitis c , virology , virus , transplantation , immunology , population , hepacivirus , environmental health
Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%‐30% of the HIV‐positive population. We report 2 patients with HCV‐HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti‐HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long‐term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV‐HCV–coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear. Liver Transpl 14:92–95, 2008. © 2007 AASLD.