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Graft vs. host disease after liver transplantation: A new approach is needed
Author(s) -
Perri Roman,
Assi Maha,
Talwalkar Jayant,
Heimbach Julie,
Hogan William,
Moore S. Breanndan,
Rosen Charles B.
Publication year - 2007
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.21203
Subject(s) - medicine , liver transplantation , complication , orthotopic liver transplantation , treatment modality , disease , transplantation , graft versus host disease , liver disease , surgery , modalities , social science , sociology
Graft‐vs.‐host disease (GVHD) is a rare, serious complication of orthotopic liver transplantation (OLT). We have treated 5 patients to date with GVHD after OLT. A total of 78 patients worldwide have been reported to have experienced this complication. The means by which GVHD after OLT has been managed is guided by experience with the more common GVHD that occurs after stem cell transplantation. However, despite the use of various treatment modalities, the mortality of GVHD after OLT remains high. This case series and review of the literature demonstrates that successful resolution of GVHD after OLT cannot be expected with the use of those modalities that have been tried to date. It is imperative that new treatments be applied to GVHD after OLT in order to improve the prognosis of patients with this diagnosis. Liver Transpl 13:1092–1099, 2007. © 2007 AASLD.