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Risk factors for invasive aspergillosis in living donor liver transplant recipients
Author(s) -
Osawa Makoto,
Ito Yutaka,
Hirai Toyohiro,
Isozumi Rie,
Takakura Shunji,
Fujimoto Yasuhiro,
Iinuma Yoshitsugu,
Ichiyama Satoshi,
Tanaka Koichi,
Mishima Michiaki
Publication year - 2007
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.21099
Subject(s) - medicine , liver transplantation , aspergillosis , intensive care unit , fulminant hepatic failure , living donor liver transplantation , fulminant hepatitis , surgery , univariate analysis , retrospective cohort study , hepatitis c , transplantation , hepatitis , multivariate analysis , immunology
Invasive aspergillosis (IA) is a severe complication of liver transplantation. Risk factors for IA after deceased donor liver transplantation (DDLT) have been presented in several reports, but are not well established for living donor liver transplant recipients. Here, a retrospective case‐control study was performed. Five cases with IA were investigated after living donor liver transplantation (LDLT) between January 1999 and December 2002 at Kyoto University Hospital. For comparison, living donor liver transplant recipients without IA were taken as controls. These patients had undergone LDLT 1 month before or after each IA case and had the same survival times as the latter. We evaluated the clinical and laboratory findings for both groups up until their demise. Patients with IA after LDLT had a very poor prognosis. By univariate analysis, risk factors for IA were preoperative intensive care unit stay ( P = 0.02) and preoperative steroid administration ( P = 0.02). Preoperative steroid administration for fulminant hepatitis possibly predisposed to the development of IA after LDLT. Liver Transpl 13:566–570, 2007. © 2007 AASLD.