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Combined HLA‐DR and ‐DQ disparity is associated with a stable course of ulcerative colitis after liver transplantation for primary sclerosing cholangitis
Author(s) -
Cholongitas Evangelos,
Papatheodoridis George V.,
Zappoli Paola,
Giannakopoulos Athanasios,
Patch David,
Marelli Laura,
Shusang Vibhakorn,
Kalambokis George,
Shirling Graham,
Rolando Nancy,
Burroughs A. K.
Publication year - 2007
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.21077
Subject(s) - medicine , ulcerative colitis , primary sclerosing cholangitis , gastroenterology , liver transplantation , colectomy , dysplasia , transplantation , disease
Combined disparity of human leukocyte antigen (HLA)‐DR and ‐DQ between mother and fetus is associated with less severe ulcerative colitis (UC) during pregnancy. We evaluated whether donor‐recipient HLA disparity after liver transplantation (LT) affects UC in patients with primary sclerosing cholangitis (PSC). Sixty‐nine consecutive patients with PSC underwent LT; all underwent colonoscopy before LT; 48 had UC before and 3 had de novo UC after LT. Clinical and laboratory data, activity and treatment of UC, post‐LT cytomegalovirus infection, and disparity of HLA‐A, ‐B, ‐DR, and ‐DQ for each donor‐recipient pair were evaluated. Pre‐LT quiescent UC was present in 26 patients. Post‐LT UC activity was evaluated in 36 of 51 patients with UC who had not undergone pre‐LT colectomy and who had >12 months' post‐LT survival. Of these, 16 were stable, 17 had worsened, and 3 had de novo UC. Seven required colectomy (4 for dysplasia or cancer) after LT. Post‐LT cytomegalovirus viremia was neither associated with worse UC activity ( P = 0.58) nor de novo UC. Disparity with respect to HLA‐A, ‐B, ‐DR, and ‐DQ was found in 58%, 27%, 44%, and 39% donor‐recipient pairs, respectively. Post‐LT UC course was similar with respect to single HLA disparity. However, disparity in none or only one HLA‐DR or ‐DQ was significantly associated with worse activity compared with patients with disparity at both (65% vs. 0%, P = 0.009). Logistic regression found that the disparity for both ‐DR and ‐DQ was the only factor statistically significantly associated with post‐LT UC activity. We conclude that disparity in both HLA‐DR and ‐DQ between donor and recipient is associated with stable UC activity after LT. Liver Transpl 13:552–557, 2007. © 2007 AASLD.