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Recurrent primary sclerosing cholangitis: Clinical diagnosis and long‐term management issues
Author(s) -
Gordon Fredric
Publication year - 2006
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20948
Subject(s) - medicine , primary sclerosing cholangitis , liver transplantation , liver biopsy , cholangiography , gastroenterology , biopsy , cirrhosis , bile duct , fibrosis , primary biliary cirrhosis , transplantation , disease
Key Concepts: 1 Primary sclerosing cholangitis (PSC) in the nontransplant setting is a chronic, progressive liver disease characterized by diffuse stricturing of the biliary tree, cholestatic liver enzymes, and a compatible liver biopsy. 2 Cholangiography reveals irregularity of the bile duct wall, strictures, beading, and diverticula. 3 The typical biopsy reveals inflammation and fibrosis of the interlobular and septal bile ducts, often with obliteration or biliary‐type cirrhosis. 4 The precise pathogenetic mechanism remains elusive but is assumed to be an autoimmune phenomenon. 5 For patients with end‐stage complications of PSC, such as liver failure, recurrent bacterial cholangitis, and intractable pruritus, liver transplantation is an acceptable treatment option. Liver Transpl. 12:S73–S75. 2006. © 2006 AASLD.