Premium
Conversion to sirolimus: A useful strategy for recalcitrant cutaneous viral warts in liver transplant recipient
Author(s) -
Dharancy Sébastien,
Catteau Benoît,
Mortier Laurent,
Boleslawski Emmanuel,
Declerck Nicole,
Canva Valérie,
Piette Frédéric,
Mathurin Philippe,
Pruvot François René
Publication year - 2006
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20927
Subject(s) - medicine , sirolimus , immunosuppression , liver transplantation , dermatology , transplantation , regimen , immunology
Abstract Dermatological complications following transplantation are very common and the majority of immunosuppressed transplant recipients develop some to many warts due to human papillomavirus (HPV) infection. In the setting of immunosuppression, therapeutic management may be disappointing because of the extent of the lesions in patients unable to develop a sufficient immune response directed against HPV. We report here a case of a young liver transplant recipient who developed diffuse recalcitrant HPV‐induced warts leading to an impairment of her quality of life. Taking into account the antiproliferative and cytostatic properties of the target‐of‐rapamycin (TOR) inhibitors, a new class of immunosuppressive drug, we significantly modified the immunosuppressive regimen. Conversion to sirolimus was followed by a rapid improvement of cutaneous state suggesting that this strategy may be useful for recalcitrant cutaneous viral warts in transplant recipient. Liver Transpl 12: 1883–1887, 2006. © 2006 AASLD.