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Impact of adult‐to‐adult living donor liver transplantation on access to transplantation and patients' survival: An 8‐year single‐center experience
Author(s) -
Dumortier Jérôme,
Adham Mustapha,
Ber Charles,
Boucaud Catherine,
Bouffard Yves,
Delafosse Bertrand,
Sagnard Pierre,
Boillot Olivier
Publication year - 2006
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20895
Subject(s) - medicine , liver transplantation , waiting list , transplantation , living donor liver transplantation , cadaveric spasm , surgery
While the number of candidates for liver transplantation has increased in the recent years, the pool of cadaveric donor organs has remained constant and the waiting time progressively increases. These facts led us to start a program of adult‐to‐adult living‐donor liver transplantation in 1998. The aim of this study was to compare the outcome of all patients put on the waiting list since 1998. Between January 1, 1998, and January 1, 2005, 505 patients were put on the waiting list in our center, and living donor liver transplantation was considered in 57 cases (11.3%). At the time of evaluation (April 1, 2006), liver transplantation was performed in 377 patients (46 living donor liver transplantations), and 89 patients died on waiting list. On an intention‐to‐treat basis, the 1‐year survival rate from the time of listing was 87.5% in the “living donor” group vs. 76.2% in the “cadaveric donor” group ( P < 0.05), whereas the 1‐year survival after liver transplantation was similar (92.3% vs. 86.9%). Our living donor liver transplantation program was able to improve the access to liver transplantation by reducing waiting time and the number of deaths on waiting list, despite the fact that these patients were more critically ill (liver failure and/or liver cancer). Liver Transpl 12:1770‐1775, 2006. © 2006 AASLD.