Premium
Clinicopathologic findings and outcomes of liver transplantation using grafts from donors with unrecognized and unusual diseases
Author(s) -
Pungpapong Surakit,
Krishna Murli,
Abraham Susan C.,
Keaveny Andrew P.,
Dickson Rolland C.,
Nakhleh Raouf E.
Publication year - 2006
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20641
Subject(s) - medicine , liver transplantation , amyloidosis , transplantation , alpha 1 antitrypsin deficiency , schistosomiasis , vasculitis , gastroenterology , surgery , pathology , immunology , disease , helminths
Despite certain strict criteria for suitable organ donors, some unrecognized and unusual diseases have been transmitted through liver transplantation to recipients. In the current series, we review our experience with 14 patients who underwent liver transplantation using donor grafts with unusual pathology, including amyloidosis (6), schistosomiasis (3), iron overload (2), and α‐1 antitrypsin deficiency (3). One of 6 patients who received grafts with amyloidosis developed vasculitis associated with the presence of arterial amyloid. With proper management, patients with donor schistosomiasis, iron overload and α‐1 antitrypsin deficiency appear to have outcomes comparable to liver transplantation using grafts without these findings. In conclusion, long‐term follow‐up is necessary to confirm these findings and understand the impact of using these grafts. Liver Transpl 12:310–315, 2006. © 2006 AASLD.