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Cyclosporine exposure and calcineurin phosphatase activity in living‐donor liver transplant patients: Twice daily vs. once daily dosing
Author(s) -
Fukudo Masahide,
Yano Ikuko,
Masuda Satohiro,
Katsura Toshiya,
Ogura Yasuhiro,
Oike Fumitaka,
Takada Yasutsugu,
Tanaka Koichi,
Inui Kenichi
Publication year - 2006
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20609
Subject(s) - calcineurin , medicine , dosing , liver transplantation , tacrolimus , urology , transplantation
We have compared the pharmacokinetics and pharmacodynamics of cyclosporine between once‐ and twice‐daily dosing regimens in de novo patients of living‐donor liver transplantation (LDLT). A total of 14 patients were enrolled in this study, who had received cyclosporine microemulsion (Neoral) twice a day (BID, n = 5) or once daily in the morning (QD, n = 9) after transplantation. On postoperative day (POD) 6, the QD regimen significantly increased cyclosporine exposure; the blood concentration at 2 hours postdose (C 2 ) and area under the concentration‐time curve (AUC) for 4 hours (AUC 0–4 ), compared with the BID regimen. Moreover, the area under the calcineurin (CaN) activity in peripheral blood mononuclear cells time‐curve (AUA) for 12 hours (AUA 0–12 ) and 24 hours (AUA 0–24 ) were decreased by approximately 42 and 25% with the QD regimen relative to the BID regimen, respectively. The C 2 level was significantly correlated with the AUC 0–4 (r 2 = 0.95), which was negatively related to the AUA 0–12 with a large interindividual variability (r 2 = 0.59). However, a significant correlation was found between the AUA 0–12 or AUA 0–24 and CaN activity at trough time points. According to a maximum inhibitory effect attributable to the drug (E max ) model, the mean estimates of E max and the C b value that gives a half‐maximal effect (EC 50 ) for CaN inhibition were not significantly different between the 2 groups, respectively. These findings suggest that a once daily morning administration of cyclosporine may improve oral absorption and help to provide an effective CaN inhibition early after LDLT. Furthermore, CaN activity at trough time points would be a single surrogate predictor for the overall CaN activity throughout dosing intervals following cyclosporine administration. Liver Transpl 12:292–300, 2006. © 2006 AASLD.