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High dose intravenous immunoglobulin treatment: Mechanisms of action
Author(s) -
Boros Peter,
Gondolesi Gabriel,
Bromberg Jonathan S.
Publication year - 2005
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20594
Subject(s) - medicine , antibody , intravenous use , intravenous infusions , intravenous immunoglobulins , immune system , fractionation , immunoglobulin g , immunology , pharmacology , anesthesia , chromatography , chemistry
Intravenous immunoglobulin (IVIg) treatment was introduced as replacement therapy for patients with antibody deficiencies, but evidence suggests that a wide range of immune‐mediated conditions could benefit from IVIg. The immunoglobulins are precipitated from human plasma by fractionation methods. In conclusion, the differences in basic fractionation methods and the addition of various modifications for purification, stabilization, and virus inactivation result in products significantly different from each other. (Liver Transpl 2005;11:1469–1480.)