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The contemporary role of antioxidant therapy in attenuating liver ischemia‐reperfusion injury: A review
Author(s) -
Glantzounis Georgios K.,
Salacinski Henryk J.,
Yang Wenxuan,
Davidson Brian R.,
Seifalian Alexander M.
Publication year - 2005
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20504
Subject(s) - medicine , oxidative stress , reperfusion injury , ischemia , liver transplantation , inflammation , antioxidant , pathological , shock (circulatory) , pharmacology , bioinformatics , transplantation , immunology , biochemistry , chemistry , biology
Oxidative stress is an important factor in many pathological conditions such as inflammation, cancer, ageing and organ response to ischemia‐reperfusion. Humans have developed a complex antioxidant system to eliminate or attenuate oxidative stress. Liver ischemia‐reperfusion injury occurs in a number of clinical settings, including liver surgery, transplantation, and hemorrhagic shock with subsequent fluid resuscitation, leading to significant morbidity and mortality. It is characterized by significant oxidative stress but accompanied with depletion of endogenous antioxidants. This review has 2 aims: firstly, to highlight the clinical significance of liver ischemia‐reperfusion injury, the underlying mechanisms and the main pathways by which the antioxidants function, and secondly, to describe the new developments that are ongoing in antioxidant therapy and to present the experimental and clinical evidence about the role of antioxidants in modulating hepatic ischemia‐reperfusion injury. (Liver Transpl 2005;11:1031–1047.)