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Transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured in a non‐heart beating donor
Author(s) -
Detry Olivier,
De Roover Arnaud,
de Leval Laurence,
Herens Christian,
Delwaide Jean,
Honoré Pierre,
Meurisse Michel
Publication year - 2005
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20457
Subject(s) - medicine , immunosuppression , liver transplantation , cancer , transmission (telecommunications) , kidney , surgery , liver cancer , heart transplantation , organ procurement , kidney transplantation , transplantation , electrical engineering , engineering
Transmission of an undiagnosed cancer with solid organ transplantation is a rare but dreadful event. In this paper the authors report the transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured in a Maastricht category 3 non‐heart beating donor. To the authors' knowledge this case is the first report of such a transmission with a liver graft procured in a non‐heart beating donor. The cancer transferal was diagnosed 1 year after transplantation in the recipients of the liver and of one kidney. The liver recipient died from multiple organ failure after a failed attempt of tumor resection. The kidney recipient underwent immunosuppression withdrawal and transplantectomy. Non‐heart beating donors should not be particularly at risk for undiagnosed cancer transmission if the procurement is performed according to the same rules of careful inspection of the abdominal and thoracic organs. After diagnosis of donor cancer transmission, kidney recipients should have the graft removed, and immunosuppression should be interrupted. The management of liver graft recipients is very difficult in this setting, and long‐term survival was very rarely reported. (Liver Transpl 2005;11:696–699.)