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Transplantation for hilar cholangiocarcinoma
Author(s) -
Heimbach Julie K.,
Haddock Michael G.,
Alberts Steven R.,
Nyberg Scott L.,
Ishitani Michael B.,
Rosen Charles B.,
Gores Gregory J.
Publication year - 2004
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20266
Subject(s) - medicine , liver transplantation , primary sclerosing cholangitis , intrahepatic cholangiocarcinoma , transplantation , fluorescence in situ hybridization , lesion , survival rate , gastroenterology , pathology , gene , disease , biochemistry , chemistry , chromosome
Key Points 1 Patients with primary sclerosing cholangitis (PSC) have a 8 to 12% risk of developing cholangiocarcinoma (CCA). 2 Cytologic techniques for aneuploidy such as digital image analysis and fluorescence in situ hybridization increase the detection rate for CCA. 3 Survival following resection for CCA is 20% to 40% at 5 years. 4 Survival following liver transplantation for unresectable, perihilar CCAs, mass lesion if present <3 cm, is greater than 80% at 5 years. 5 Patients with intrahepatic CCAs are not eligible for liver transplantation. (Liver Transpl 2004;10:S65–S68.)