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Selection of candidates with HCC for transplantation in the MELD era
Author(s) -
Sala Margarita,
Varela Maria,
Bruix Jordi
Publication year - 2004
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20263
Subject(s) - medicine , economic shortage , liver transplantation , donation , waiting list , transplantation , cadaveric spasm , randomized controlled trial , surgery , selection (genetic algorithm) , intensive care medicine , hepatocellular carcinoma , organ donation , resection , linguistics , philosophy , artificial intelligence , government (linguistics) , computer science , economics , economic growth
Key Points 1 Liver transplantation is the main option for patients with early HCC who are not optimal candidates for surgical resection. 2 Shortage of donors is its main limitation, as waiting for a liver allows the tumor to progress and induce exclusion from the waiting list and death. 3 The absence of randomized controlled trials hinders the establishment of the most effective therapy to prevent tumor progression while waiting. 4 Live donation may be a cost‐effective approach if optimal results are expected and the mortality risk for the donor is kept below .3%. 5 Priority policies have to be developed and refined to provide a fair and effective distribution of cadaveric organs. (Liver Transpl 2004;10:S4–S9.)