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Liver transplantation for neuroendocrine tumors: Progress and uncertainty
Author(s) -
Rosado Barbara,
Gores Gregory J.
Publication year - 2004
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20148
Subject(s) - medicine , debulking , liver transplantation , neuroendocrine tumors , endocrine system , pancreas , resection , hepatectomy , transplantation , surgery , hormone , cancer , ovarian cancer
Metastases from neuroendocrine tumors (NET) of the gastrointestinal tract, carcinoids, and endocrine pancreatic tumors (EPT) can be limited to the liver for long periods and may have slow growth. The symptoms are often related to hormone overproduction, and debulking surgery—for example, liver resection—is recommended to achieve tumor remission or symptom palliation. If liver resection is not feasible, hepatectomy and orthotopic liver transplantation (OLT) have been proposed. For EPT where the primary tumor is located in the head of the pancreas it may be advantageous to resect the primary tumor and the liver metastases en bloc and perform a multivisceral transplantation (MVTx). (Transplant Proc 2003;35:809–810.)