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Immunosuppression affects the rate of recurrent primary biliary cirrhosis after liver transplantation
Author(s) -
Neuberger James,
Gunson Bridget,
Hubscher Stefan,
Nightingale Peter
Publication year - 2004
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20123
Subject(s) - medicine , immunosuppression , liver transplantation , primary biliary cirrhosis , calcineurin , tacrolimus , odds ratio , gastroenterology , confidence interval , risk factor , cirrhosis , transplantation , multivariate analysis
Identifying the risk factors associated with recurrence of primary biliary cirrhosis after liver transplantation may affect immunosuppression and increase understanding of the pathogenesis. Four hundred eighty‐five patients with PBC were followed for a median of 79 months after transplantation; histological evidence of recurrence was found in 23%. On multivariate analysis, the only risk factor identified with recurrence was the type of calcineurin inhibitor used. The odds ratio for recurrence on tacrolimus was 2.73 (95% confidence interval: 1.84–4.10) compared with cyclosporine. For those receiving cyclosporine, the median time to recurrence was 123 months and for those on tacrolimus 62 months ( P < .001). Reasons for this difference between the 2 calcineurin inhibitors are not clear. (Liver Transpl 2004;10:488–491.)