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Hepatitis B virus genotype A and D and clinical outcomes of liver transplantation for HBV‐related disease
Author(s) -
Girlanda Raffaele,
Mohsen Abdul H,
Smith Heather,
Sablon Erwin,
Yuen ManFung,
O'Grady John,
Muiesan Paolo,
Rela Mohamed,
Heaton Nigel,
Norris Suzanne
Publication year - 2004
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.20004
Subject(s) - medicine , genotype , hbsag , liver transplantation , hepatitis b virus , liver disease , transplantation , coinfection , genotyping , hepatitis b , virology , gastroenterology , immunology , virus , biology , gene , biochemistry
Hepatitis B virus (HBV) genotypes have been associated with specific patterns of disease and response to antiviral therapy. We investigated the effect of HBV genotype on HBV recurrence and mortality after liver transplantation (LT). Pretransplant sera of 45 hepatitis B surface antigen (HBsAg) positive adults were submitted for HBV genotyping by a reverse‐phase hybridization line probe assay with genotype‐specific probes. Data were correlated with clinical outcomes after transplantation. Genotype A (n =15), D (n = 13) and A/D (n = 12) accounted for 89% of all genotypes. Coinfection with two HBV genotypes was encountered in 14 (31.1%) patients. Eighteen patients (40 %) developed HBV recurrence at a median of 10 months posttransplant (range, 1–53) and 10 patients (22 %) died at a median of 24 months (range, 3–63). Genotype D patients were more likely to develop HBV recurrence or die compared with genotype A patients, although this did not reach statistical significance. Dual infection with genotype A/D resulted in mortality similar to that of genotype A but recurrence similar to that of genotype D. Active viral replication at time of transplantation was the only independent factor ( P = 0.03) that predicted HBV recurrence. In conclusion, HBV genotype A and D did not have a significant impact on clinical outcomes of LT for HBV‐related liver disease in patients of European origin. These data do not support routine HBV genotyping in liver transplantation. (Liver Transpl 2004;10:58–64.)