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Q‐Switched Nd:YAG (532 nm) Laser Versus Intra‐Dermal Tranexamic Acid for Treatment of Facial Ephelides: A Split Face, Randomized, Comparative Trial
Author(s) -
Sayed Khadiga S.,
Tuqan Samar,
Hilal Rana F.
Publication year - 2021
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.23291
Subject(s) - tranexamic acid , medicine , hyperpigmentation , surgery , laser treatment , nd:yag laser , randomized controlled trial , laser , dermatology , blood loss , physics , optics
Background and Objectives To compare the efficacy and safety of intradermal injection of tranexamic acid (TXA) versus Q switched (QS) KTP (532 nm) in the treatment of facial ephelides. Study Design/Materials and Methods A randomized comparative split‐face study included a total of 30 female patients with bilateral facial ephelides. One cheek was treated by intra‐dermal TXA injections and the other was treated by QS‐KTP (532 nm). Patient assessment was performed by photography, pigmentation area, severity index and spectrophotometry at baseline, 1 week after treatment, and 2 months after treatment. Results A significant difference was found between both sides regarding the percentage change of pigmentation area, severity score (PSI) and melanin index (MI) after treatment and during follow up, favoring laser ( P = 0.001). PSI decreased after treatment by 66.5% and 15.4% (laser and TXA sides respectively), further decrease after follow‐up was 69.4% with laser and 26.1% with TXA. MI improved by 3.7% after KTP laser to 7.7% after follow‐up and by 2.4% after TXA injections to 6.5% after follow‐up. Four patients developed post‐inflammatory hyperpigmentation following QS‐KTP. Conclusion QS‐KTP laser is superior to intradermal TXA injection in the treatment of facial ephelides. Lasers Surg. Med. © 2020 Wiley Periodicals LLC