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Device‐Induced Neocollagenesis: Profibrotic Response or True Neocollagenesis?
Author(s) -
Natari Sheila,
Kim Ko Eun,
Ryu Sook In,
Park Ji Hyun,
Kim IlHwan
Publication year - 2020
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.23258
Subject(s) - procollagen peptidase , transforming growth factor , matrix metalloproteinase , chemistry , wound healing , in vivo , fibrosis , matrix (chemical analysis) , growth factor , biomedical engineering , medicine , pathology , surgery , biology , biochemistry , receptor , microbiology and biotechnology , chromatography
Background and Objectives Many light and radiofrequency‐based rejuvenation devices have claimed to increase collagen production in the skin dermal tissue. However, there has not been enough scientific evidence to prove whether the result is just a profibrotic response or not. We aimed to find the optimal skin rejuvenation device that shows true neocollagenesis. Study Design/Materials and Methods We evaluated dermal collagen thickness and gene expression of procollagen type 1, 3, matrix metalloproteinase‐3 (MMP‐3), and transforming growth factor‐β (TGF‐β) resulting from different energy‐based devices in a rat model in vivo . The wound‐healing response was evaluated histologically and by real‐time polymerase chain reaction (RT‐PCR) at immediate, 1st, 2nd, 4th, 8th, and 12th week after the initial procedure. Results At the 12th week, the most relevant changes of the dermal thickness were found in specimens after treatment with electrosurgical unit, fractional CO 2 and 1064 nm Q‐switched Nd:YAG. Procollagen 1 and 3 were also found to be the highest in electrosurgical unit, fractional CO 2 , and microneedle radiofrequency. Dramatic changes of MMP‐3 and TGF‐β were remarkable at the early observation but went back to normal level at 12th week. The ratio of procollagen 1 and 3 was found to be the lowest with Q‐Switched Nd:YAG 1064 nm and fractional CO 2 . Conclusion Electrosurgical unit resulted in most significant changes, but due to irreversible thermal damage and extremely high procollagen results it is considered as a profibrotic response. Fractional CO 2 and Q‐Switched Nd:YAG 1064 nm are applicable to face skin rejuvenation treatment considering thickening of dermal tissue and lower procollagen 1:3 ratio similar to the neocollagenesis purpose. Lasers Surg. Med. © 2020 Wiley Periodicals LLC