Premium
Innovative 1064‐nm Nd:YAG Laser Significantly Improves Keratosis Pilaris, A Randomized, Double‐Blind, Sham‐Irradiation‐Controlled Trial
Author(s) -
Maitriwong Praewvanid,
Tangkijngamvong Natsinee,
Asawada Pravit
Publication year - 2020
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.23184
Subject(s) - medicine , erythema , hyperpigmentation , dermatology , hypopigmentation , randomized controlled trial , surgery
Background and Objective Keratosis pilaris (KP) is a common follicular disorder for which various topical agents and energy‐based devices have been used with some efficacy. To evaluate the efficacy of a novel 1064‐nm Nd:YAG laser for the reduction of skin roughness, erythema, and hyperpigmentation in KP subjects. Study Design/Materials and Methods Twenty‐three subjects with untreated KP on the upper outer arms participated in a randomized, single‐blind fashion. One arm of each subject was divided into upper and lower parts. One part was randomized to be treated with an innovative 1064‐nm Nd:YAG laser, while the other part received sham irradiation. Subjects received four consecutive treatments at 4‐week intervals. Antera3D was used to measure skin roughness, erythema, and hyperpigmentation at baseline and 4 weeks after the last treatment. Moreover, clinical outcomes were also evaluated by subjects' Global Improvement Score (GIS) and subjects' satisfaction grading scores. Results Twenty‐three subjects completed the study. There was statistically significant reduction of skin roughness measured by Antera3D compared with control group ( P < 0.001). There were statistically significant improvements of skin roughness, erythema, hyperpigmentation, and overall appearances graded by subjects' Global Improvement Score ( P < 0.001 all). Subjects' satisfaction scores were graded significantly better in treatment parts ( P < 0.001). No adverse events including burning, bulla, erosion, post‐inflammatory hyper/hypopigmentation, and scar formation developed in any subjects throughout the study period. Conclusion This innovative 1064‐nm Nd:YAG laser has proved to significantly and safely reduce skin roughness in Thai KP subjects compared with control after four sessions. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.