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Randomized, Controlled Early Intervention of Dynamic Mode Fractional Ablative CO 2 Laser on Acute Burn Injuries for Prevention of Pathological Scarring
Author(s) -
Waibel Jill S.,
Gianatasio Chloe,
Rudnick Ashley
Publication year - 2020
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.23170
Subject(s) - medicine , erythema , randomized controlled trial , surgery , ablative case , burn injury , pathological , laser treatment , radiation therapy , laser , physics , optics
Background and Objectives This study challenges the currently accepted treatment parameters of waiting 1 year following burn injury to treat the resultant scarring. It assesses the impact of treating burn and trauma wounds at less than 3 months of injury on scar formation, providing a new temporal paradigm to patients in the prevention and minimization of scar formation. Study Design/Materials and Methods This randomized clinical trial included 19 patients with moderate‐to‐severe acute burn injuries less than 3 months from injury. The treatment areas underwent three fractional ablative CO 2 laser treatments at 8‐week intervals. The primary outcomes were improvement in the Manchester Scar Scale (MSS) and photography. Secondary outcomes were optical coherence tomography (OCT), treatment time, immediate post‐treatment response, and histology. Results Upon blinded evaluation, 100% of treatment areas were correctly identified when compared with control. MSS scores before and after treatment were totaled with an averaged sum of 13.33 per scar at baseline to 8.39 after treatment, a 63% average improvement versus control ( P < 0.001). Histology and OCT demonstrated a re‐organization of the underlying skin structure. The average treatment time was 18 minutes. Immediate post‐treatment responses were limited to mild‐to‐moderate erythema. Conclusions Early intervention with ablative fractional laser on acute traumatic wounds resulted in significant decrease of scar formation compared with untreated areas on the same wounds, providing an impactful new time course to treat severe burn and trauma injuries. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.