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Toward assessment of resection margins using hyperspectral diffuse reflection imaging (400–1,700 nm) during tongue cancer surgery
Author(s) -
Brouwer de Koning Susan G.,
Weijtmans Pim,
Karakullukcu M. Baris,
Shan Caifeng,
Baltussen Elisabeth J. M.,
Smit Laura A.,
Veen Robert L. P.,
Hendriks Benno H. W.,
Sterenborg Henricus J. C. M.,
Ruers Theo J. M.
Publication year - 2020
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.23161
Subject(s) - hyperspectral imaging , tongue , medicine , near infrared spectroscopy , radiology , nuclear medicine , pathology , optics , remote sensing , geology , physics
Background and Objectives There is a clinical need to assess the resection margins of tongue cancer specimens, intraoperatively. In the current ex vivo study, we evaluated the feasibility of hyperspectral diffuse reflectance imaging (HSI) for distinguishing tumor from the healthy tongue tissue. Study Design/Materials and Methods Fresh surgical specimens ( n = 14) of squamous cell carcinoma of the tongue were scanned with two hyperspectral cameras that cover the visible and near‐infrared spectrum (400–1,700 nm). Each pixel of the hyperspectral image represents a measure of the diffuse optical reflectance. A neural network was used for tissue‐type prediction of the hyperspectral images of the visual and near‐infrared data sets separately as well as both data sets combined. Results HSI was able to distinguish tumor from muscle with a good accuracy. The diagnostic performance of both wavelength ranges (sensitivity/specificity of visual and near‐infrared were 84%/80% and 77%/77%, respectively) appears to be comparable and there is no additional benefit of combining the two wavelength ranges (sensitivity and specificity were 83%/76%). Conclusions HSI has a strong potential for intra‐operative assessment of tumor resection margins of squamous cell carcinoma of the tongue. This may optimize surgery, as the entire resection surface can be scanned in a single run and the results can be readily available. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.