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Efficacy and safety of intense pulsed light with a KTP filter for the treatment of solar lentigines
Author(s) -
Friedmann Daniel P.,
Peterson Jennifer D.
Publication year - 2019
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.23056
Subject(s) - medicine , intense pulsed light , tolerability , potassium titanyl phosphate , adverse effect , surgery , dermatology , laser , physics , optics
Background Optical energy‐based devices, including intense pulsed light (IPL) and potassium titanyl phosphate (KTP) lasers achieve reduction of pigmented and vascular lesions in a relatively similar number of treatments. This study aimed to evaluate the efficacy and safety of an IPL with a “KTP‐like” filter emitting a wavelength of 525–585 nm for the treatment of solar lentigines on the hands and face. Methods This was a single center, prospective, open‐label clinical trial including 16 healthy Caucasian subjects (15 females, mean age, 55 years; skin types II and III) with hand and facial solar lentigines. Subjects were treated with three IPL treatment sessions with a KTP‐like filter conducted at monthly intervals. Follow‐up evaluations were performed 1, 3, and 6 months after the last treatment session. Overall pigmentation improvement, pigmentation clearance per lesion, adverse events, and subject tolerability to treatment were evaluated. Results Significant improvements in facial and hand pigmentation were noted at all follow‐up visits ( P < 0.0001). One month after the last treatment session, good to excellent outcomes were noted in 74.6% of treated facial areas and 90% of treated hand regions. Although the effect of treatment gradually declined in both treatment regions over the 6‐month follow‐up period, over 60% of subjects demonstrated good to excellent results at the study end. Clinical effectiveness was further confirmed by the reduction in Melanin Index (MI) following each treatment as compared to baseline. Downtime and complications were minimal. Conclusions IPL treatment with a KTP‐like filter is a well‐tolerated and effective method for reducing facial and hand pigmentation. Lasers Surg. Med. 51:500–508, 2019. © 2019 Wiley Periodicals, Inc.